Increased concentrations of the NH2-terminal fragment of gastrin-17 in acute duodenal ulcer and acute gastritis.

Abstract

The concentration of the NH2-terminal fragment of gastrin-17 in serum was determined by radioimmunochemistry. Two antisera were used, one specific for the COOH-terminus and the other for the NH2-terminus of gastrin-17. The NH2-terminal gastrin-17 immunoreactivity in unfractionated serum correlated well with the amount of fragment found after gel filtration of the same sera (p less than 0.001). In healthy subjects (no. = 100), the NH2- and COOH-terminal gastrin immunoreactivity was 8 +/- 1 and 20 +/- 1 pmol/l (mean +/- SEM), respectively. In patients with acute duodenal ulcer (no. = 30) and acute gastritis (no. = 10) the NH2-terminal immunoreactivity was fourfold increased compared with in healthy subjects (p less than 0.001), whereas the COOH-terminal was identical, the NH2- and COOH-terminal concentrations being 33 +/- 7 and 22 +/- 2 pmol/l in duodenal ulcer and 35 +/- 6 and 21 +/- 1 pmol/l in acute gastritis. Other groups of patients had NH2- and COOH-terminal gastrin concentrations in serum similar to those measured in healthy subjects. The results suggest that gastrin cells process gastrin-17 abnormally during the acute phase of duodenal ulcer and gastritis.

• Authors: B Petersen, B N Andersen
• Journal: Scandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 18 Issue 5 Pg. 635-41 (Jul 1983) ISSN: 0036-5521 [Print] England
• PMID: 6675184 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gastrins
• Peptide Fragments
• gastrin 17

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Amino Acid Sequence
• Chromatography, Gel
• Duodenal Ulcer (blood)
• Female
• Gastrins (blood)
• Gastritis (blood)
• Humans
• Male
• Middle Aged
• Peptide Fragments (blood)
• Radioimmunoassay