Increased efficacy of liposomes-encapsulated praziquantel in treatment of opisthorchiasis in hamsters.

Abstract

An increased efficacy of liposomes-encapsulated praziquantel was observed in the treatment of hamster opisthorchiasis. A single intracardial dose of 1.5 mg/kg of encapsulated praziquantel is as effective as an intracardial dose of 30 mg/kg or an oral dose of 100 mg/kg of free praziquantel. The suppressing activity of both free and liposomes-encapsulated praziquantel significantly decrease as the infection times increase from 1 to 5 weeks, suggesting that the young liver flukes are more susceptible to praziquantel than the adult flukes.

• Authors: P Ruenwongsa, W Thamavit
• Journal: The Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 14 Issue 4 Pg. 501-4 (Dec 1983) ISSN: 0125-1562 [Print] Thailand
• PMID: 6673127 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Isoquinolines
• Liposomes
• Praziquantel

Topics

• Animals
• Cricetinae
• Isoquinolines (therapeutic use)
• Liposomes (administration & dosage)
• Mesocricetus
• Opisthorchiasis (drug therapy)
• Praziquantel (therapeutic use)