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Coagulation, fibrinolysis, platelet and kinin-forming systems during toxemia of pregnancy.

Abstract
The coagulation, fibrinolysis, and platelet and kinin-forming systems were studied during toxemia of pregnancy by multifactorial examinations. In severe toxemia of pregnancy, decreases in extrinsic coagulation factors, platelet, antithrombin III, plasminogen, alpha 2-plasmin inhibitor, and increases in soluble fibrin-monomer complex, fibrin degradation products, beta-thromboglobulin were observed. This suggests that intravascular coagulation, induced probably through the extrinsic pathway and secondary fibrinolysis, is associated with toxemia of pregnancy. Prekallikrein increased during pregnancy but decreased rapidly with onset of labor. The same changes were observed in high molecular weight kininogen, indicating that kinin may be generated, which would contribute to the uterine contraction during labor. The prekallikrein level was significantly low during severe toxemia.
AuthorsM Maki
JournalBiological research in pregnancy and perinatology (Biol Res Pregnancy Perinatol) Vol. 4 Issue 4 Pg. 152-4 ( 1983) ISSN: 0724-438X [Print] Germany
PMID6652168 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Prekallikrein
Topics
  • Blood Coagulation
  • Female
  • Fibrinolysis
  • Humans
  • Platelet Count
  • Platelet Function Tests
  • Pre-Eclampsia (blood)
  • Pregnancy
  • Prekallikrein (analysis)

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