Modification of the size of developing infarcts in the ligated dog heart by betahistine-HCL.

Abstract

The effectiveness of beta-histine-HCL in modifying the size of developing myocardial infarcts was tested in the surgically ligated dog. Branches of the left coronary artery were ligated and a 6-hour continuous intravenous infusion of 0.24 mg/kg/min of beta-histine was administered from 0 to 120 min after ligation. The effect of this treatment was evaluated histologically in studies on acute ischemia by the use of the hematoxylin-basic fuchsin-picric acid stain for early myocardial ischemia. The treatment was also evaluated grossly in a study on chronic ischemia where the dogs were permitted to survive for 30 days before sacrifice. In these experiments the size of infarcts found in the beta-histine-treated animals was compared with those found in the saline controls. Both studies showed that the control ligations produced a large uniform area of ischemia or infarction that was greatly reduced or prevented by immediate treatment with beta-histine. Also, beta-histine was capable of significantly reducing the size of developing infarcts for up to 120 min after ligation.

• Authors: L Terracio, W G Kubicek
• Journal: Acta anatomica (Acta Anat (Basel)) Vol. 101 Issue 4 Pg. 372-9 ( 1978) ISSN: 0001-5180 [Print] Switzerland
• PMID: 665141 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Pyridines
• Vasodilator Agents
• Betahistine

Topics

• Animals
• Betahistine (therapeutic use)
• Collateral Circulation (drug effects)
• Coronary Circulation (drug effects)
• Dogs
• Drug Evaluation, Preclinical
• Ligation
• Myocardial Infarction (pathology, prevention & control)
• Myocardium (pathology)
• Pyridines (therapeutic use)
• Vasodilator Agents (therapeutic use)