[Efficacy of penicillin therapy of meningococcal infection in children undergoing different regimes of pathogenetic therapy].

Abstract

The course of meningococcal infection and nonspecific and specific immunity in children subjected to different regimens of pathogenetic therapy were studied. It was shown that the clinico-immunological indices were more favourable in children treated with lasix as a diuretic agent. Recovery with defects was observed in 6.8 per cent of the children of this group, while in patients subjected to routine treatment the respective value amounted to 14.6 per cent. The use of lasix in combination with penicillin increased the efficacy of penicillin therapy and shortened the recovery period by 8.4 +/- 0.2 days as compared to that of routine treatment. No unfavourable effect of elevated penicillin concentrations on the lysozyme activity, blood bactericidal characteristics and composition of immunoglobulins A, M and G in the children was recorded.

• Authors: I A Vereshchagin, T I Kovalenko, L T Kurakina
• Journal: Antibiotiki (Antibiotiki) Vol. 28 Issue 10 Pg. 764-7 (Oct 1983) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' penitsillinoterapii meningokokkovoĭ infektsii u deteĭ pri razlichnykh rezhimakh patogeneticheskogo lecheniia.
• PMID: 6651266 (Publication Type: English Abstract, Journal Article)

Chemical References

• Immunoglobulins
• Penicillins
• Furosemide
• Muramidase

Topics

• Adolescent
• Blood Bactericidal Activity
• Child
• Child, Preschool
• Drug Therapy, Combination
• Furosemide (administration & dosage)
• Humans
• Immunoglobulins (analysis)
• Infant
• Meningitis, Meningococcal (drug therapy)
• Meningococcal Infections (drug therapy)
• Muramidase (blood)
• Penicillins (administration & dosage)
• Sepsis (drug therapy)
• Syndrome