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Efficacy and tolerance of enteric-coated erythromycin base (Ery-Max) administered twice or four times daily in patients with acute bronchitis.

Abstract
We performed a double-blind trial of a new formulation of erythromycin base as enteric-coated pellets (Ery-Max) in the treatment of acute bronchitis in 220 patients. Subjects were randomized to receive either 500 mg twice or 250 mg four times a day for 10 days. The response to treatment as assessed clinically and by changes in sputum purulence was the same in the two groups. Thus 97% and 98% of the patients had a good or improved clinical effect. Treatment was well tolerated, but side-effects were encountered more often in the q.i.d. group (p greater than 0.05). In conclusion, the study showed that the enteric-coated erythromycin as pellets, given twice or four times daily for 10 days, was well tolerated and equally effective in acute bronchitis. Hence, the more convenient b.i.d. regimen can be recommended.
AuthorsP S Pekkanen, K Josefsson
JournalThe Journal of international medical research (J Int Med Res) Vol. 11 Issue 5 Pg. 285-8 ( 1983) ISSN: 0300-0605 [Print] England
PMID6642069 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Delayed-Action Preparations
  • Tablets, Enteric-Coated
  • Erythromycin
Topics
  • Acute Disease
  • Adult
  • Bronchitis (drug therapy)
  • Delayed-Action Preparations
  • Double-Blind Method
  • Drug Administration Schedule
  • Erythromycin (administration & dosage)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Random Allocation
  • Tablets, Enteric-Coated

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