Oral diazepam premedication reduces the incidence of post-succinylcholine muscle pains.

Abstract

In a prospective, double-blind placebo controlled trial, the effect of oral diazepam premedication on post-succinylcholine fasciculations and myalgia was studied. Forty patients undergoing septoplasty procedures received orally identical capsules containing either 10 mg of diazepam or a placebo 90 minutes preoperatively. A standardized anaesthetic regimen included induction with 5 mg X kg-1 of thiopental and 1 mg X kg-1 of succinylcholine. The diazepam and control groups did not differ significantly in extent of fasciculations or ease of intubation. However, only 15 per cent of the diazepam premedicated patients had myalgias postoperatively compared to 50 per cent of the control patients, a statistically significant difference (p = 0.04).

• Authors: A O Davies
• Journal: Canadian Anaesthetists' Society journal (Can Anaesth Soc J) Vol. 30 Issue 6 Pg. 603-6 (Nov 1983) ISSN: 0008-2856 [Print] Canada
• PMID: 6640397 (Publication Type: Journal Article)

Chemical References

• Succinylcholine
• Diazepam

Topics

• Adult
• Diazepam (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Muscular Diseases (chemically induced, prevention & control)
• Nausea (prevention & control)
• Pain, Postoperative (prevention & control)
• Preanesthetic Medication
• Random Allocation
• Succinylcholine (adverse effects)