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Absence of serum-stimulated lipase activity and altered lipid content in milk from a patient with type I hyperlipoproteinaemia.

Abstract
We measured the serum-stimulated lipase activity, fatty acid content, and various biochemical parameters in the breast milk of a lactating mother suffering from familial lipoprotein lipase deficiency and of healthy control subjects. Serum-stimulated lipase activity was virtually undetectable in milk from our patient and the total fatty acid content was low. The fatty acid composition differed from normal showing a marked absolute and relative increase in the content of lauric (C12:0) and myristic (C14:0) fatty acids and considerably reduced levels of oleic (C18:1) and especially linoleic (C18:2) acids. Other fatty acid species showed lesser changes in concentration. Besides a reduced calcium concentration in the milk from our patient, other biochemical parameters were not significantly different from control subjects.
AuthorsG M Berger, A Spark, P M Baillie, J Huskisson, G Stockwell, E van der Merwe
JournalPediatric research (Pediatr Res) Vol. 17 Issue 10 Pg. 835-9 (Oct 1983) ISSN: 0031-3998 [Print] United States
PMID6634247 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Fatty Acids
  • Fatty Acids, Essential
  • Fatty Acids, Nonesterified
  • Lipids
  • Lipoprotein Lipase
  • Calcium
Topics
  • Adult
  • Calcium (analysis)
  • Fatty Acids (analysis)
  • Fatty Acids, Essential (analysis)
  • Fatty Acids, Nonesterified (analysis)
  • Female
  • Humans
  • Hyperlipoproteinemia Type I (enzymology)
  • Hyperlipoproteinemias (enzymology)
  • Lactation
  • Lipids (analysis)
  • Lipoprotein Lipase (metabolism)
  • Milk, Human (analysis, enzymology)
  • Pregnancy
  • Pregnancy Complications (enzymology)

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