Phase I-II study of 120-hour infused 5-FU and split-course radiation therapy in localized non-small cell lung cancer.

Abstract

Thirty patients with locally advanced nonresectable non-small cell bronchogenic carcinoma were studied for tolerance and response to 120-hour continuously infused 5-FU (IFU) combined with chest x-ray therapy. The IFU was escalated in patient groups from 20 to 35 mg/kg/24 hours. Radiation was also escalated in patient subsets from 200 to 400 rads/fraction using a split-course technique to a total dose of 5000 rads. Tolerance was exceeded by IFU doses of 35 mg/kg/day. The complete response rate was ten of 28 patients (36%); a complete response was associated with a significantly prolonged survival. Radiosensitization of lung cancer by IFU appears clinically feasible in man.

• Authors: J E Byfield, W Stanton, T R Sharp, S S Frankel, J Koziol
• Journal: Cancer treatment reports (Cancer Treat Rep) Vol. 67 Issue 10 Pg. 933-6 (Oct 1983) ISSN: 0361-5960 [Print] United States
• PMID: 6627237 (Publication Type: Journal Article)

Chemical References

• Fluorouracil

Topics

• Aged
• Combined Modality Therapy
• Drug Evaluation
• Female
• Fluorouracil (administration & dosage, adverse effects)
• Humans
• Lung Neoplasms (mortality, radiotherapy, therapy)
• Male
• Middle Aged