Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy.

Abstract

We have demonstrated for the first time alpha-1 adrenergic, beta-adrenergic, and muscarinic cholinergic receptors in human nasal mucosa obtained from patients with nasal allergy or sinusitis. Using the radioligand 3H-prazosin, 3H-dihydroalprenolol (3H-DHA) and 3H-quinaclidinyl benzilate (3H-QNB), we determined the receptor densities (Bmax) and affinities (KD) of alpha-1, beta, and muscarinic receptors. There was an increased number of muscarinic receptors and a decreased number of alpha-1, beta receptors in patients with nasal allergy but not in those with sinusitis. Binding affinities (KD) of alpha-1, beta, and muscarinic receptors were unchanged in all patients with nasal allergy and sinusitis. Disorders of the autonomic nerve receptors appear to play a definite role in pathology of nasal allergy.

• Authors: T Ishibe, T Yamashita, T Kumazawa, C Tanaka
• Journal: Archives of oto-rhino-laryngology (Arch Otorhinolaryngol) Vol. 238 Issue 2 Pg. 167-73 ( 1983) ISSN: 0302-9530 [Print] Germany
• PMID: 6626029 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Adrenergic
• Receptors, Muscarinic
• Dihydroalprenolol
• Quinuclidinyl Benzilate
• Prazosin

Topics

• Adult
• Dihydroalprenolol (metabolism)
• Female
• Humans
• Kinetics
• Male
• Nasal Mucosa (metabolism)
• Prazosin (metabolism)
• Quinuclidinyl Benzilate (metabolism)
• Radioligand Assay
• Receptors, Adrenergic (metabolism)
• Receptors, Muscarinic (metabolism)
• Rhinitis, Allergic, Perennial (metabolism)
• Sinusitis (metabolism)