Sinus histiocytosis with massive lymphadenopathy: remission with chemotherapy.

Abstract	A case of sinus histiocytosis with massive lymphadenopathy (SHML) is reported, in which the patient had severe life-threatening complications resulting from SHML. The disease process was extensive involving the respiratory tract, skeleton, integument, orbit and eyelid, uveal tract, and the lymphatic system. Treatment with cytotoxic agents (chlorambucil, prednisone) resulted in resolution of the airway obstruction and was effective in managing these severe complications with minimal observed toxicity.
Authors	C R Suarez, W P Zeller, S Silberman, G Rust, H Messmore
Journal	The American journal of pediatric hematology/oncology (Am J Pediatr Hematol Oncol) Vol. 5 Issue 3 Pg. 235-41 ( 1983) ISSN: 0192-8562 [Print] United States
PMID	6625106 (Publication Type: Case Reports, Journal Article)
Chemical References	Chlorambucil Prednisone
Topics	Biopsy Child Chlorambucil (therapeutic use) Female Humans Lymph Nodes (pathology) Lymphatic Diseases (complications, drug therapy) Prednisone (therapeutic use) Syndrome

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