HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Development and activation of brown fat in rats with pheochromocytoma PC 12 tumors.

Abstract
To study the neurohormonal determinism of cellular growth and differentiation and mitochondrial development in brown adipose tissue (BAT), this organ was analyzed in rats bearing uncloned or cloned (PC 12) pheochromocytoma; comparison was made with cold adaptation. Both uncloned and PC 12 tumors induced an enlargement of tissue weight and DNA total content, although smaller than during cold adaptation. The following striking modifications were observed in rats bearing PC 12 tumors: strong vasodilation, increase in protein and phospholipid percentage, alteration of the fatty acid composition of phospholipids, increase in mitochondrial protein, large increase of the GDP binding to isolated mitochondria, and marked rise in specific amount of 32,000-dalton uncoupling protein (ascertained using immunological approach). It is concluded that secretions of PC 12 tumors can induce the same alterations in BAT as does the sympathetic system during cold adaptation of animals. An important contribution of norepinephrine to these effects is evidenced, but a specific function of other trophic factors secreted by PC 12 cells and by sympathetic nerves can be postulated.
AuthorsD Ricquier, G Mory, M Nechad, M Combes-George, J Thibault
JournalThe American journal of physiology (Am J Physiol) Vol. 245 Issue 3 Pg. C172-7 (Sep 1983) ISSN: 0002-9513 [Print] United States
PMID6614154 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Fatty Acids
  • Phospholipids
Topics
  • Acclimatization
  • Adipose Tissue, Brown (pathology, physiopathology)
  • Adrenal Gland Neoplasms (physiopathology)
  • Animals
  • Cell Line
  • Cell Transformation, Neoplastic
  • Cold Temperature
  • Fatty Acids (analysis)
  • Neoplasms, Experimental (physiopathology)
  • Pheochromocytoma (physiopathology)
  • Phospholipids (analysis)
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: