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No acute effect of pimozide on the plasma GH levels in acromegaly.

Abstract
In 34 acromegalic patients either untreated or inadequately treated by surgery and/or radiotherapy the plasma GH levels and plasma Prl levels were determined during 8 h after the acute administration of the dopamine agonist bromocriptine and during 150 min after the administration of the dopamine antagonist pimozide. A 50% or more suppression of the basal GH levels was arbitrarily defined as a positive response. Seventeen patients displayed a positive response to bromocriptine, 17 patients displayed a negative response to bromocriptine. Plasma Prl levels were elevated in 6 of 17 bromocriptine responders and in 2 of 17 bromocriptine nonresponders. There was no difference in the plasma GH response to pimozide administration in the patients with a positive or a negative GH response to bromocriptine. With one exception there was in no patient a positive GH response to pimozide. In further experiments the plasma GH response to pimozide was measured during 11 h in 6 bromocriptine sensitive and 6 bromocriptine insensitive patients. Again no difference was found between bromocriptine responders and non-responders. There was also no difference in the Prl response to bromocriptine or pimozide between GH responders and GH non-responders. The Prl response to pimozide was blunted in comparison to a control group. The present study does not not lend support to the idea that there is a fundamental difference in the degree of hypothalamic dopaminergic control of GH or Prl secretion between bromocriptine sensitive and bromocriptine insensitive patients with acromegaly.
AuthorsJ W Nortier, R J Croughs, G H Donker, J H Thijssen, F Schwarz
JournalActa endocrinologica (Acta Endocrinol (Copenh)) Vol. 103 Issue 4 Pg. 461-8 (Aug 1983) ISSN: 0001-5598 [Print] Denmark
PMID6613492 (Publication Type: Journal Article)
Chemical References
  • Receptors, Dopamine
  • Pimozide
  • Bromocriptine
  • Prolactin
  • Growth Hormone
Topics
  • Acromegaly (blood, drug therapy)
  • Adult
  • Aged
  • Bromocriptine (pharmacology)
  • Female
  • Growth Hormone (blood)
  • Humans
  • Male
  • Middle Aged
  • Pimozide (pharmacology)
  • Prolactin (blood)
  • Receptors, Dopamine (drug effects)

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