[Factors responsible for increasing the cytogenetic effectiveness of cyclophosphamide administered to irradiated animals. Frequency of chromosome aberrations in locally irradiated rat bone marrow cells].

Abstract

A study was made of the frequency of chromosome aberrations induced by cyclophosphamide (CP) in the bone marrow of preirradiated rats (exposure of crus with the body shielded, and vice versa). A reliable evidence was obtained in favor of a change in the metabolism of CP in the irradiated body which was the cause of the enhancement of its cytogenetic action.

• Authors: T K Iakovleva, N P Ponomareva
• Journal: Radiobiologiia (Radiobiologiia) 1983 Jul-Aug Vol. 23 Issue 4 Pg. 542-4 ISSN: 0033-8192 [Print] Russia (Federation)
• Vernacular Title: Izuchenie prichin, obuslovlivaiushchikh usilenie tsitogeneticheskoĭ éffektivnosti tsiklofosfana pri vvedenii ego obluchennym zhivotnym. Issledovanie chastoty indutsirovannykh khromosomnykh aberratsiĭ v kletkakh kostnogo mozga krys pri lokal'nom obluchenii.
• PMID: 6611885 (Publication Type: English Abstract, Journal Article)

Chemical References

• Mutagens
• Cyclophosphamide

Topics

• Animals
• Bone Marrow (drug effects, radiation effects)
• Chromosome Aberrations
• Cyclophosphamide (pharmacology)
• Male
• Mutagens
• Radiation Injuries, Experimental (genetics)
• Rats