Digital ulcers/gangrene and immunoglobulin classes/complement fixation of anti-dsDNA in systemic lupus erythematosus patients.

Abstract

The immunoglobulin classes/complement fixation of anti-dsDNA were studied in sera obtained from 17 systemic lupus erythematosus (SLE) patients with digital ulcers and/or gangrene (Group A); 13 SLE patients with leg ulcer, peripheral neuropathy or livedo (Group B); 24 SLE patients with Raynaud's phenomenon (Group C); and 18 SLE patients with active lupus nephritis (Group D). Antibodies to dsDNA of IgG and IgA classes were commonly present (often in high titers) in Groups A and D. However, complement fixation of anti-dsDNA was more common in Group D than in any of the other 3 groups.

• Authors: H Hashimoto, H Tsuda, Y Takasaki, N Fujimaki, M Suzuki, Y Shiokawa
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 10 Issue 5 Pg. 727-32 (Oct 1983) ISSN: 0315-162X [Print] Canada
• PMID: 6606040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Antinuclear
• Antigen-Antibody Complex
• Complement System Proteins
• DNA

Topics

• Antibodies, Antinuclear (analysis)
• Antigen-Antibody Complex (analysis)
• Complement System Proteins (analysis)
• DNA (immunology)
• Female
• Gangrene (immunology)
• Humans
• Lupus Erythematosus, Systemic (immunology)
• Male
• Skin Ulcer (immunology)