IgE levels and PMN chemotaxis in atopic dermatitis.

Abstract

In the recent years immunological abnormalities, including defective polymorphonuclear neutrophils (PMN) chemotaxis and both quantitative and functional defects in T-lymphocytes, have been reported in atopic dermatitis (AD). To date there is still a controversy regarding the causes of PMN chemotaxis defect and the possible mechanism underlying this abnormality in patients with AD. The aim of this study was to investigate the PMN chemotactic function in 18 children affected with AD and high levels of serum IgE, and in 4 children with Hyper IgE Syndrome (HIES). Our results showed a marked PMN chemotaxis defect (p less than 0.01) in the patients with HIES, while in the subjects with AD PMN cellular chemotaxis was normal and there was no correlation between the results of chemotaxis and serum IgE levels.

• Authors: E Galli, P Rossi, L Fiore, R Perlini, F Celiboni, P Betti, L Businco
• Journal: Allergologia et immunopathologia (Allergol Immunopathol (Madr)) 1983 May-Jun Vol. 11 Issue 3 Pg. 189-94 ISSN: 0301-0546 [Print] Singapore
• PMID: 6605080 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin E

Topics

• Adolescent
• Chemotaxis, Leukocyte
• Child
• Child, Preschool
• Dermatitis, Atopic (immunology)
• Female
• Humans
• Hypergammaglobulinemia (immunology)
• Immunoglobulin E (analysis)
• Male
• Neutrophils (immunology)
• T-Lymphocytes (immunology)