Crossreaction of monoclonal anti-T-cell antibodies: implications for classifying B-cell leukemias.

Abstract

Cell samples from 62 patients with B-cell leukemias (33 CLL, 8 IC, 6 PLL, 4 HCL, 2 ALL and 9 other NHL) were tested with a series of monoclonal antibodies (A50, T101, Lyt2, Leu 1, M203) directed against T cells and shown to crossreact with B-CLL. The results demonstrate a heterogeneity of B-cell leukemias as all typical cases of CLL were reactive whereas most other cases were negative. Using the fluorescence-activated cell sorter, a somewhat stronger reaction was seen in early or benign cases of CLL, compared to advanced cases. All B-cell leukemias tested expressed the Ia antigen.

• Authors: R Munker, E Thiel, U Kummer, H Rodt, S Thierfelder
• Journal: Blut (Blut) Vol. 46 Issue 2 Pg. 95-100 (Feb 1983) ISSN: 0006-5242 [Print] Germany
• PMID: 6600407 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Adult
• Aged
• Antibodies, Monoclonal (immunology)
• B-Lymphocytes (immunology)
• Cross Reactions
• Female
• Humans
• Leukemia, Hairy Cell (immunology)
• Leukemia, Lymphoid (classification, immunology)
• Lymphoma (immunology)
• Male
• Middle Aged
• T-Lymphocytes (immunology)