Abstract |
The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.
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Authors | J R Rodríguez, E L Mariño, M J Otero, J R Commes, J Garcia, J M Rodriguez, F Lozano, A Dominguez-Gil, A G Alonso |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 26
Issue 5
Pg. 787-8
(Nov 1984)
ISSN: 0066-4804 [Print] United States |
PMID | 6595964
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Appendectomy
- Cefmetazole
- Cephamycins
(blood, therapeutic use)
- Female
- Humans
- Male
- Muscles
(metabolism)
- Skin
(metabolism)
- Surgical Wound Infection
(prevention & control)
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