Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.

Abstract

The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.

• Authors: J R Rodríguez, E L Mariño, M J Otero, J R Commes, J Garcia, J M Rodriguez, F Lozano, A Dominguez-Gil, A G Alonso
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 26 Issue 5 Pg. 787-8 (Nov 1984) ISSN: 0066-4804 [Print] United States
• PMID: 6595964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cephamycins
• Cefmetazole

Topics

• Administration, Topical
• Adolescent
• Adult
• Appendectomy
• Cefmetazole
• Cephamycins (blood, therapeutic use)
• Female
• Humans
• Male
• Muscles (metabolism)
• Skin (metabolism)
• Surgical Wound Infection (prevention & control)