Abstract |
A simple method has been developed whereby chlormethiazole, ethchlorvynol and trichloroethanol can be simultaneously detected and measured in biological fluids. The procedure is based upon the rapid extraction of a small (50-microliter) sample volume with an equal volume of chloroform containing an internal standard, followed by the gas-liquid chromatographic analysis of this extract. Specimens of blood plasma or serum, urine and gastric contents can be used, and no interference from either endogenous or exogenous sources has been observed. The method is suitable for the measurement of the plasma concentrations of these compounds attained after overdosage.
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Authors | R J Flanagan, T D Lee, D M Rutherford |
Journal | Journal of chromatography
(J Chromatogr)
Vol. 153
Issue 2
Pg. 473-9
(Jun 11 1978)
Netherlands |
PMID | 659564
(Publication Type: Journal Article)
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Chemical References |
- Chlorohydrins
- Chlormethiazole
- Ethchlorvynol
- Ethylene Chlorohydrin
- 2,2,2-trichloroethanol
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Topics |
- Chlormethiazole
(blood, poisoning, urine)
- Chlorohydrins
(blood, poisoning, urine)
- Chromatography, Gas
- Chromatography, Liquid
- Ethchlorvynol
(blood, poisoning, urine)
- Ethylene Chlorohydrin
(analogs & derivatives)
- Humans
- Poisoning
(blood, urine)
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