[Clinical experience of sisomicin sulfate by intravenous drip infusion for the treatment of infection complicated by malignant disease].

Abstract

Sisomicin sulfate (SISO) was used for the treatment of infections complicated by malignant diseases in 10 cases; 4 cases with suspicious sepsis, 2 with pneumonia, 2 with urinary tract infection, 1 with renal abscess and 1 with cholecystitis. SISO was administered by intravenous drip infusion at daily dose from 100 to 150 mg for 6 to 12 days, concomitantly with other antibiotics. Clinical results were as follows; Good in 2, fair in 5, poor in 3 cases. As to the side effects of SISO, cylindruria with aggravation of microscopic hematuria and elevations of GOT, GPT and A1-P were observed each one of them, respectively. The relationship to the SISO, however, was not clear. In view of the above results, the drip infusion of SISO may be useful for the treatment of serious infection complicated by malignant diseases.

• Authors: K Tamura, Y Araki, T Amamoto, M Seita
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 37 Issue 7 Pg. 1237-40 (Jul 1984) ISSN: 0368-2781 [Print] Japan
• PMID: 6593472 (Publication Type: English Abstract, Journal Article)

Chemical References

• Sisomicin

Topics

• Adult
• Aged
• Humans
• Infusions, Parenteral
• Leukemia (complications)
• Leukemia, Myeloid, Acute (complications)
• Middle Aged
• Sepsis (drug therapy)
• Sisomicin (administration & dosage, therapeutic use)
• Urinary Tract Infections (drug therapy)