[Cysteine activity in the poisoning of animals by various aliphatic series halogenated hydrocarbons].

Abstract

In poisoning animals with various aliphatic series haloid-hydrocarbons (LK99 and LD99) free cysteine was found to be a group antidote in rats poisoned with monohaloid-hydrocarbons. It was established that the therapeutic activity of cystein depends not on the nature of haloid and double bonds, but on the number of the haloid atoms in a molecule, the length, ramification and nature of the radical. A good durative action are shown by such cystein derivatives as acetyl-cysteine, glutathione and cystein salts. In poisoning with haloid-alkyls dithiol antidotes (unithiol, mecaptide, BAL) and other drugs proved ineffective.

• Authors: G V Bakhishev
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1978 May-Jun Vol. 41 Issue 3 Pg. 342-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Aktivnost' tsisteina pri intoksikatsii zhivotnykh razlichnymi galoiduglevodorodami alifaticheskogo riada.
• PMID: 658385 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antidotes
• Hydrocarbons, Halogenated
• Glutathione
• Cysteine
• Acetylcysteine

Topics

• Acetylcysteine (therapeutic use)
• Animals
• Antidotes
• Cysteine (therapeutic use)
• Drug Evaluation, Preclinical
• Glutathione (therapeutic use)
• Hydrocarbons, Halogenated (poisoning)
• Rats
• Time Factors