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Fluorescence microscopical study of 5-hydroxytryptamine storage organelles in mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome).

Abstract
The number and fluorescence intensity of fluorescent granules (5-HT storage organelles) of mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) are decreased compared to those of control mice platelets. This indicates both quantitative and qualitative changes of the 5-HT organelles, namely a reduced number and a reduced storage capacity, respectively.
AuthorsH P Lorez, M Da Prada
JournalExperientia (Experientia) Vol. 34 Issue 5 Pg. 663-4 (May 15 1978) ISSN: 0014-4754 [Print] Switzerland
PMID658263 (Publication Type: Journal Article)
Chemical References
  • Serotonin
  • Quinacrine
Topics
  • Animals
  • Blood Platelets (metabolism)
  • Chediak-Higashi Syndrome (blood)
  • Histocytochemistry
  • Mice
  • Microscopy, Fluorescence
  • Quinacrine (metabolism)
  • Serotonin (metabolism)

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