Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections.

Abstract

704 patients with intestinal nematode infestation were treated with oxantel and oxantel-pyrantel in either liquid or tablet form, at doses from 10 to 25mg/kg. All were given the drug or drugs as a single dose. In 699 patients with trichuriasis cure rates between 64 and 93% were obtained and there were egg reduction rates of between 90 and 100%. The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. Only mild side-effects were noted. The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection.

• Authors: J K Lim
• Journal: Drugs (Drugs) Vol. 15 Suppl 1 Pg. 99-103 ( 1978) ISSN: 0012-6667 [Print] New Zealand
• PMID: 657998 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Pyrimidines
• Styrenes
• Pyrantel

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Drug Combinations
• Feces (parasitology)
• Female
• Humans
• Intestinal Diseases, Parasitic (drug therapy, parasitology)
• Male
• Middle Aged
• Nematode Infections (drug therapy, parasitology)
• Parasite Egg Count
• Pyrantel (therapeutic use)
• Pyrimidines (therapeutic use)
• Styrenes (therapeutic use)