HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Anti-prostaglandin and anti-inflammatory short-term efficacy of piroxicam in rheumatoid arthritis.

Abstract
The efficacy of anti-inflammatory agents is related to their concentration in the peripheral compartments. In rheumatoid arthritis a drug's affinity for synovial tissue and synovial fluid is a decisive factor in treatment. The short-term efficacy of piroxicam was studied, relating the synovial concentration of prostaglandins and acid phosphatase and LDH to piroxicam synovial and plasma levels. After withdrawal of synovial fluid for pre-treatment measurements, 10 patients received 20 to 30 mg of piroxicam/day for eight days. The drug reached an average level of 3.56 +/- 0.9 micrograms/ml in synovial fluid, and 7.73 +/- 1.6 micrograms/ml in plasma. The acid phosphatase decreased from an initial average level of 29 mu/ml to a final average level of 15.999 mu/ml. The LDH showed an initial average level of 725.3 mu/ml and a final average of 471.2 mu/ml (p less than 0.01). The prostaglandin levels were quantified by two methods: indirectly, by measuring the malonilaldehyde concentration in nMol/ml, which showed an average level decrease of 48.75% in 100% of the cases; and directly, by means of thin layer chromatography and biological assay on rats' gastric fundus, against controls. The disappearance of PGE1 and a significant decrease in PGF2 alpha (100%) were observed. We conclude that piroxicam is an effective drug for the short-term treatment of rheumatoid arthritis. It penetrates rheumatoid synovial fluid, reaching 50% plasma concentrations. It has an anti-prostaglandin action, and could stabilize lysosomal membrane.
AuthorsA Strusberg, H Montrull, C I Meirovich
JournalEuropean journal of rheumatology and inflammation (Eur J Rheumatol Inflamm) Vol. 6 Issue 1 Pg. 41-5 ( 1983) ISSN: 0140-1610 [Print] ENGLAND
PMID6574910 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Prostaglandin Antagonists
  • Prostaglandins E
  • Prostaglandins F
  • Thiazines
  • Piroxicam
  • Dinoprost
  • L-Lactate Dehydrogenase
  • Acid Phosphatase
  • Alprostadil
Topics
  • Acid Phosphatase (metabolism)
  • Adult
  • Alprostadil
  • Anti-Inflammatory Agents (therapeutic use)
  • Arthritis, Rheumatoid (drug therapy)
  • Dinoprost
  • Humans
  • L-Lactate Dehydrogenase (metabolism)
  • Middle Aged
  • Piroxicam
  • Prostaglandin Antagonists (therapeutic use)
  • Prostaglandins E (metabolism)
  • Prostaglandins F (metabolism)
  • Synovial Fluid (cytology, metabolism)
  • Thiazines (blood, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: