Physiologic features of hemolysis axxociated with altered cation and 2,3-diphosphoglycerate content.

Abstract

A hemolytic disorder characterized by altered RBC cation composition (increases Na, decreases K), reduced monovalent cation content (decreased Na + K/liter RBC), and decreased levels of 2,3-diphosphoglycerate (2,3-DPG) is described. The etiology of these RBC abnormalities was not elucidated following extensive laboratory evaluation, although two important physiologic principles were manifested by this case: (1) Hemolysis was relatively well compensated (41% hematocrit) despite a significantly decreased RBC survival (51 Cr t 1/2 = 10.5 days). This effect presumably was due to reduced 2,3-DPG content (1.9 mumol/ml RBC) and the associated increase in whole blood oxygen affinity (P50 = 19.6 mm hg). (2) RBC size and water content were normal in spite of marked cation depletion. This anomaly was thought to reflect the osmotic effects of reduced polyvalent anion (2,3-DPG) content.

• Authors: M M Albala, N L Fortier, B E Glader
• Journal: Blood (Blood) Vol. 52 Issue 1 Pg. 135-41 (Jul 1978) ISSN: 0006-4971 [Print] United States
• PMID: 656623 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Glucose
• Cations, Monovalent
• Diphosphoglyceric Acids
• Lactates
• Sodium
• Potassium

Topics

• Adolescent
• Blood Glucose (metabolism)
• Cations, Monovalent
• Child
• Diphosphoglyceric Acids (metabolism)
• Erythrocyte Aging
• Erythrocytes (metabolism)
• Female
• Hemolysis
• Humans
• Lactates (biosynthesis)
• Potassium (metabolism)
• Sodium (metabolism)