[Use of chromogenic substrates for estimation of indicators of kallikrein-kinin and blood coagulation systems in blood plasma of patients with nephrotic syndrome].

A distinct increase of kallikrein content in blood plasma of patients with nephrotic syndrome as well as activation of thrombin simultaneously with a decrease in the prothrombin level were recorded in samples with synthetic chromogenic substrates S-2160 (Bz-Phe-Val-Arg-pNa), S-2238 (D-Phe-Pip-Arg-pNA) and S-2302 (D-Pro-Phe-Arg-pNA). Limited proteolysis of prothrombin by blood plasma kallikrein appears to be among the possible reasons of thrombin activation in the patients with nephrotic syndrome. Activity of plasmin, measured with S-2251 (D-Val-Leu-Lys-pNA) as a chromogenic substrate, was practically unlatered in blood plasma of these patients.
AuthorsI P Baskova, T S Paskhina, L R Poliantseva, R I Iakubovskaia, A Tiero
JournalVoprosy medit︠s︡inskoĭ khimii (Vopr Med Khim) 1983 Sep-Oct Vol. 29 Issue 5 Pg. 96-9 ISSN: 0042-8809 [Print] USSR
Vernacular TitleOtsenka s pomoshch'iu khromogennykh substratov pokazateleĭ kallikrein-kininovoĭ i svertyvaiushcheĭ sistem v plazme krovi bol'nykh s nefroticheskim sindromom.
PMID6557709 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Blood Coagulation Factors
  • Chromogenic Compounds
  • Kinins
  • Oligopeptides
  • Kallikreins
  • Blood Coagulation Factors (metabolism)
  • Chromogenic Compounds
  • Humans
  • Kallikreins (blood)
  • Kinetics
  • Kinins (blood)
  • Nephrotic Syndrome (blood)
  • Oligopeptides
  • Substrate Specificity

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