Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.

Abstract

A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.

• Authors: W Koek, J H Woods, K C Rice, A E Jacobson, P N Huguenin, T R Burke Jr
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 106 Issue 3 Pg. 635-8 (Nov 27 1984) ISSN: 0014-2999 [Print] Netherlands
• PMID: 6542865 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• 1-(1-phenylcyclohexyl)-3-methylpiperidine
• Ketamine
• Pentobarbital
• Phencyclidine

Topics

• Animals
• Catalepsy (chemically induced)
• Columbidae
• Dose-Response Relationship, Drug
• Humans
• Ketamine (pharmacology)
• Pentobarbital (pharmacology)
• Phencyclidine (analogs & derivatives, pharmacology)
• Stereoisomerism