HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immune thrombocytopenia and Gaucher's disease.

Abstract
A 35-year-old Ashkenazi woman with Gaucher's disease was evaluated for persistent thrombocytopenia. The diagnosis of Gaucher's disease was made by bone marrow aspiration and confirmed by the determination of glucocerebrosidase levels in leukocytes and cultured skin fibroblasts. Studies of platelet-associated IgG and in vivo platelet survival demonstrated immune-mediated destruction of platelets consistent with immune thrombocytopenic purpura. A trial of prednisone had no effect on the platelet count. Total splenectomy resulted in a complete and prolonged remission. The clinical implications of Gaucher's disease and concurrent immune thrombocytopenic purpura are discussed.
AuthorsT J Lester, G A Grabowski, J Goldblatt, I Z Leiderman, C G Zaroulis
JournalThe American journal of medicine (Am J Med) Vol. 77 Issue 3 Pg. 569-71 (Sep 1984) ISSN: 0002-9343 [Print] United States
PMID6540988 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Immunoglobulin G
Topics
  • Adult
  • Blood Platelets (immunology)
  • Female
  • Gaucher Disease (complications, immunology)
  • Humans
  • Immunoglobulin G (analysis)
  • Purpura, Thrombocytopenic (complications, immunology)
  • Splenomegaly (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: