A comparison between the efficacy of thiabendazole and febantel on experimental trichinellosis in rats.

Abstract	Febantel at a dose level of 5 mg kg-1 had a lethal efficacy of 54.1% against the adult worm and 69.5% against the migrating larvae of Trichinella spiralis in rats. When administered at 15 mg kg-1, it demonstrated lethal effects of 94.4, 92.5 and 74.7% against adult, young and encysted larvae, respectively. Infected rats treated with 300 mg kg-1 died. Thiabendazole had efficiencies of 96.4 and 83.3% against intestinal and migrating early muscle phases, respectively, and was 42% effective against the encysting phase.
Authors	H A Alcaíno, T R Gorman, M B Elorrieta
Journal	Veterinary parasitology (Vet Parasitol) Vol. 14 Issue 2 Pg. 153-7 (Mar 1984) ISSN: 0304-4017 [Print] Netherlands
PMID	6538721 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anthelmintics Guanidines Thiabendazole febantel
Topics	Animals Anthelmintics (therapeutic use) Female Guanidines (therapeutic use) Muscles (parasitology) Rats Rats, Inbred Strains Thiabendazole (therapeutic use) Trichinella (drug effects, growth & development) Trichinellosis (drug therapy, parasitology)

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