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High CSF lactate and pyruvate content in Kearns-Sayre syndrome.

Abstract
We studied lactate and pyruvate concentrations in CSF and blood of a patient with Kearns-Sayre syndrome (KSS), 3 patients with ocular myopathy and 11 normal control subjects. We found significant elevation of lactate and pyruvate in the CSF of the patient with KSS, suggesting a disorder of CNS lactate-pyruvate metabolism.
AuthorsM Kuriyama, M Suehara, N Marume, M Osame, A Igata
JournalNeurology (Neurology) Vol. 34 Issue 2 Pg. 253-5 (Feb 1984) ISSN: 0028-3878 [Print] United States
PMID6538023 (Publication Type: Case Reports, Comparative Study, Journal Article)
Chemical References
  • Lactates
  • Pyruvates
Topics
  • Adult
  • Female
  • Humans
  • Kearns-Sayre Syndrome (cerebrospinal fluid, pathology)
  • Lactates (cerebrospinal fluid)
  • Male
  • Middle Aged
  • Mitochondria, Muscle (ultrastructure)
  • Ophthalmoplegia (cerebrospinal fluid)
  • Pyruvates (cerebrospinal fluid)

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