Effects of vitamin E in kid erythrocytes on Tween 20-induced hemolysis in vitro.

Abstract

Red blood cells (RBC) of alpha-tocopherol sufficiency and deficiency were produced in kids fed on purified diets to investigate the relationship between RBC alpha-tocopherol levels and hemolysis induced by Tween 20. RBC alpha-tocopherol contents of vitamin E-deficient kids were non-detectable from 4 weeks, and percentages of hemolysis increased to over 70%. A highly significant decrease in hemolysis was noted when vitamin E was added to the diet. Tween 20 hemolysis values were negatively correlated with RBC tocopherol levels in kids. The concentration of RBC alpha-tocopherol required to prevent the hemolysis was found to be 0.6 microgram/ml packed cells.

• Authors: K Hodate, T Hamada
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 30 Issue 6 Pg. 509-14 (Dec 1984) ISSN: 0301-4800 [Print] Japan
• PMID: 6533271 (Publication Type: Journal Article)

Chemical References

• Polysorbates
• Vitamin E

Topics

• Animals
• Animals, Newborn
• Diet
• Erythrocytes (metabolism)
• Goats (blood)
• Hemolysis (drug effects)
• In Vitro Techniques
• Plasma (metabolism)
• Polysorbates (pharmacology)
• Vitamin E (administration & dosage, blood)
• Vitamin E Deficiency (blood, veterinary)