Red cell glutathione in Leber's optic atrophy.

Abstract	Red cell glutathione has been assayed in a family affected by Leber's optic atrophy. The results are in agreement with a defective cyanide metabolism. The transmission mechanism of the disease is discussed. Lastly, a preventive and therapeutic approach is proposed.
Authors	L Cotticelli, E Rinaldi, L D'Alessandro, S Russo, T Libondi, C Costagliola
Journal	Metabolic ophthalmology, pediatric and systemic (Metab Ophthalmol) 1984-1985 Vol. 8 Issue 1 Pg. 31-4 ISSN: 0883-9522 [Print] United States
PMID	6521627 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cyanides Methionine Glutathione Cysteine Hydroxocobalamin
Topics	Adult Cyanides (metabolism) Cysteine (therapeutic use) Diet Erythrocytes (metabolism) Glutathione (blood) Humans Hydroxocobalamin (therapeutic use) Male Metabolism, Inborn Errors (drug therapy) Methionine (therapeutic use) Optic Atrophy (blood, drug therapy, genetics) Pedigree Smoking

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