[Colony-forming ability of bone marrow hematopoietic cells in mice with transplanted leukemia during administration of carminomycin].

Abstract

Effects of carminomycin on the colony-forming ability of bone marrow haemopoietic stem cells (CFUs) were compared in normal mice with steady state and actively regenerating bone marrow, and in P-388 and La leukemia-bearing mice. CFUs assays were performed 24 h after treatment of donor mice with the increasing doses of the drug. Leukemia-bearing mice received carminomycin on the 5th day after transplantation. The dose-effect curves were exponential for CFUS normal mice with both the steady state and active proliferation state of bone marrow. The maximal effect was found 24 h after injection of 0.7 mg/kg of carminomycin (ED50 for CFUS) being more pronounced in regenerating bone marrow. The dose-effect curves for leukemias were also exponential. In the case of La leukemia the killing of CFUs by carminomycin was the highest as compared with P-388 leukemia.

• Authors: G I Kozinets, L E Ivanova, O K Khanykova, T V Kuznetsova, N A Rudneva
• Journal: Eksperimental'naia onkologiia (Eksp Onkol) Vol. 6 Issue 5 Pg. 59-62 ( 1984) ISSN: 0204-3564 [Print] Ukraine
• Vernacular Title: Kolonieobrazuiushchaia sposobnost' gemopoéticheskikh kletok kostnogo mozga mysheĭ s perevivnym leĭkozom pri vvedenii karminomitsina.
• PMID: 6510345 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carubicin
• Daunorubicin

Topics

• Animals
• Carubicin (therapeutic use, toxicity)
• Colony-Forming Units Assay
• Daunorubicin (analogs & derivatives)
• Female
• Hematopoietic Stem Cells (drug effects, pathology)
• Leukemia P388 (drug therapy, pathology)
• Leukemia, Experimental (drug therapy, pathology)
• Mice
• Mice, Inbred CBA
• Neoplasm Transplantation
• Rats