Studies of phenylalanine hydroxylase activity in patients with chronic renal failure: the effect of haemodialysis.

Abstract

The effect of serum from patients with renal failure on phenylalanine hydroxylase activity has been measured in normal individuals, patients with steady-state chronic renal failure and patients undergoing haemodialysis. Significant inhibition of enzyme activity was induced by serum from patients with steady-state chronic renal failure but not from patients undergoing haemodialysis. Inhibitor(s) was readily diffusible in vitro and appeared to have an approximate molecular mass of 800. The results suggest that the low-plasma tyrosine levels observed in patients with chronic renal failure are due, at least in part, to the inhibition of phenylalanine hydroxylase.

• Authors: C Stonier, E H McGale, G M Aber
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 143 Issue 2 Pg. 115-22 (Nov 15 1984) ISSN: 0009-8981 [Print] Netherlands
• PMID: 6509772 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tyrosine
• Phenylalanine Hydroxylase

Topics

• Adult
• Aged
• Chromatography, Gel
• Female
• Humans
• Kidney Failure, Chronic (enzymology, therapy)
• Male
• Middle Aged
• Phenylalanine Hydroxylase (antagonists & inhibitors, blood)
• Renal Dialysis
• Tyrosine (blood)