Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea.

Abstract

Piroxicam, a non-steroidal anti-inflammatory agent, was administered in the feed to rats which had been inoculated intra-rectally with N-methylnitrosourea (MNU). When examined 5 months later, the piroxicam-treated rats had a significant reduction of intestinal tumors compared to tumor incidences and tumor numbers in rats which were fed drug-free diet. There was no evidence of toxicity associated with the consumption of piroxicam.

• Authors: M Pollard, P H Luckert
• Journal: Cancer letters (Cancer Lett) Vol. 25 Issue 2 Pg. 117-21 (Dec 1984) ISSN: 0304-3835 [Print] Ireland
• PMID: 6509432 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Thiazines
• Piroxicam
• Methylnitrosourea

Topics

• Animals
• Body Weight
• Diet
• Intestinal Neoplasms (chemically induced, drug therapy)
• Male
• Methylnitrosourea
• Piroxicam
• Rats
• Rats, Inbred Strains
• Thiazines (therapeutic use)