Viral neuraminidase and cellular ectosialyltransferase in human lymphoblastoid cells infected with influenza virus.

Abstract

In human lymphoblastoid cells, infected with an influenza virus, Fowl Plague Virus (FPV), glycoproteins (such as secreted IgM) are hyposialylated, through the action of viral neuraminidase. In this study, the modulation of the cellular ectosialyltransferase activity during viral infection was investigated. This activity was detectable in FPV-infected cells, was shown to be 2.5-fold higher than that of uninfected cells, and to be able to restore, at least partially, the level of sialylation of the cell surface acceptors.

• Authors: M Duc Dodon, R Cecchelli, R Cacan, L Gazzolo, A Verbert
• Journal: Biochimie (Biochimie) Vol. 66 Issue 6 Pg. 493-6 (Jun 1984) ISSN: 0300-9084 [Print] France
• PMID: 6498232 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycoproteins
• Membrane Proteins
• Transferases
• Sialyltransferases
• Neuraminidase

Topics

• Cell Line
• Cell Membrane (metabolism)
• Cell Transformation, Viral
• Clostridium (enzymology)
• Glycoproteins (metabolism)
• Humans
• Influenza A virus (enzymology)
• Kinetics
• Lymphocytes
• Membrane Proteins (metabolism)
• Neuraminidase (metabolism)
• Sialyltransferases (metabolism)
• Transferases (metabolism)