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Efficacy of fenbendazole against inhibited larvae of Ostertagia ostertagi in yearling cattle.

Abstract
Efficacy of fenbendazole, at doses of 7.5 and 10.0 mg/kg of body weight, against inhibited early 4th-stage larvae of Ostertagia ostertagi and other nematodes of the abomasum and intestinal tract, was investigated in naturally infected yearling heifers in late May 1982. In Louisiana, this is near the end of the period (March to May) in which maximal numbers of inhibition-prone larvae are acquired. The mean numbers of O ostertagi in 10 untreated control cattle were: adults, 4,880; developing 4th-stage larvae, 12,546; and inhibited early 4th-stage larvae, 167,931. At the 7.5 mg/kg dose level (10% liquid suspension) in 10 cattle, percentage reduction of O ostertagi in comparison with controls was: adults, 95.7%; developing 4th stages, 91.1%; and inhibited 4th stage, 55.0%. Percentage reductions of other genera were as follows: abomasum--Trichostrongylus axei, 99.6%; Haemonchus sp, 95.1%; intestinal tract--Cooperia spp, 97.8%; Trichostrongylus colubriformis, 100.0%; and Oesophagostomum radiatum 4th stage and adults, 100.0%. At the 10.0 mg/kg dose (10% liquid suspension) in 11 cattle, the percentage reduction of O ostertagi in comparison with controls was: adults, 98.6%; developing 4th stages, 92.9%; and inhibited 4th stage, 80.0%. Percentage reductions of other genera were: abomasum--T axei, 99.9%; Haemonchus sp, 98.8%; intestinal tract--Cooperia spp, 99.3%; T colubriformis, 100.0%; and Oes radiatum 4th stage and adults, 100.0%. Variability of efficacy against inhibited larvae was observed, particularly at the 7.5 mg/kg dose; at this dose, 7 of the 10 heifers in the group yielded in excess of 54,000 surviving larvae.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsJ C Williams, J W Knox, K S Marbury, M D Kimball, S W Scheide, T G Snider, M U David
JournalAmerican journal of veterinary research (Am J Vet Res) Vol. 45 Issue 10 Pg. 1989-93 (Oct 1984) ISSN: 0002-9645 [Print] United States
PMID6497097 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Benzimidazoles
  • Fenbendazole
Topics
  • Animals
  • Benzimidazoles (pharmacology)
  • Cattle
  • Cattle Diseases (drug therapy)
  • Feces (parasitology)
  • Female
  • Fenbendazole (pharmacology, therapeutic use)
  • Intestinal Diseases, Parasitic (drug therapy, veterinary)
  • Larva (drug effects)
  • Ostertagiasis (drug therapy, veterinary)
  • Parasite Egg Count (veterinary)
  • Seasons
  • Trichostrongyloidea (drug effects)
  • Trichostrongyloidiasis (veterinary)

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