Marked hypotonic polyuria resulting from nephrogenic diabetes insipidus with partial sensitivity to vasopressin.

Abstract

We studied two women with severe hypotonic polyuria whose symptoms dated from infancy. We eliminated the possibility of central diabetes insipidus (DI) and primary polydipsia, and established the presence of nephrogenic DI on the basis of: 1) the interrelationships between plasma osmolality, urine osmolality, and urinary AVP; and 2) impaired antidiuretic responses to AVP and 1 deamino-8-D-arginine vasopressin. Though 25-50 times as resistant to 1 deamino-8-D-arginine vasopressin nasal spray as patients with central DI, these patients could be treated effectively with large doses of the nasal spray. One patient has been so treated for more than a year with dramatic improvement in her polydipsia, polyuria, and sense of well-being.

• Authors: A M Moses, S J Scheinman, A Oppenheim
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 59 Issue 6 Pg. 1044-9 (Dec 1984) ISSN: 0021-972X [Print] United States
• PMID: 6490792 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Arginine Vasopressin
• Deamino Arginine Vasopressin

Topics

• Administration, Intranasal
• Adult
• Arginine Vasopressin (metabolism, therapeutic use)
• Deamino Arginine Vasopressin (administration & dosage, therapeutic use)
• Diabetes Insipidus (complications, drug therapy)
• Drug Resistance
• Female
• Humans
• Kidney Concentrating Ability (drug effects)
• Kidney Diseases (complications, drug therapy)
• Polyuria (etiology)
• Thirst