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Effects of methaqualone on blood platelet function.

Abstract
To study the mechanism whereby toxic doses of methaqualone cause a bleeding tendency in humans, the effects of methaqualone, diphenhydramine, and the combination of methaqualone plus diphenhydramine on blood platelet function were investigated. Exposure of human platelets in platelet-rich plasma in vitro to final concentrations of methaqualone ranging from 1.1 to 4.5 X 10(-4)) M resulted in nearly complete inhibition of the secondary phase and significant inhibition of the primary phase of adenosine diphosphate (ADP)--induced aggregation. Both the slope and height of collagen-induced aggregation responses were reduced significantly in vitro by the drug. When methaqualone final concentrations of 1.1, 2.3, and 4.5 X 10(-4) M were studied in the presence of diphenhydramine (1.1, 2.3, and 4.5 X 10(-5) M, respectively), the degree of inhibition of ADP-induced aggregation was only slightly greater (not significant) than that observed with methaqualone. The platelets of rabbits injected intravenously with methaqualone, 10 mg/kg, demonstrated a significantly decreased ability to aggregate with ADP and collagen 30 and 60 min after administration of the drug. These results suggest that a drug-induced defect of blood platelet function may play a role in the bleeding associated with methaqualone toxicity.
AuthorsD G Mills
JournalClinical pharmacology and therapeutics (Clin Pharmacol Ther) Vol. 23 Issue 6 Pg. 685-91 (Jun 1978) ISSN: 0009-9236 [Print] United States
PMID648081 (Publication Type: Journal Article)
Chemical References
  • Drug Combinations
  • Adenosine Diphosphate
  • Methaqualone
  • Diphenhydramine
  • Collagen
Topics
  • Adenosine Diphosphate (pharmacology)
  • Adult
  • Animals
  • Collagen (pharmacology)
  • Diphenhydramine (pharmacology)
  • Drug Combinations
  • Female
  • Humans
  • In Vitro Techniques
  • Male
  • Methaqualone (blood, pharmacology)
  • Platelet Aggregation (drug effects)
  • Rabbits

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