HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of antifeins (memory affecting agents) on behavior, brain infraslow activity and temperature.

Abstract
Four imidazole- and pyrazoledicarboxylic acid derivatives: 1-ethyl-4,5-di-(N-methylcarbamoyl)-imidazole (aethimizol), 1-allyl-4,5-di(N-methylcarbamoyl)-imidazole (allylnorantifein), 1-ethyl-4,5-di-(N-methylcarbamoyl)-pyrazole (IEM-476), and 1-allyl-4,5-di-(N-methylcarbomyol)-pyrazole (IEM-474) were investigated for their ability to abolish in rats the amnesia of passive avoidance response induced by electroconvulsive shock and to alter the infraslow activity and temperature of the brain in rabbits. IEM-476 10 mg/kg did abolish (P less than 0,05) the amnesia in rats, while the other agents did not. The experiments in rabbits with brain indwelling golden electrodes and thermocouples revealed a shift in the amplitude and frequency of multiminute waves of infraslow activity and a decrease in the temperature of hippocampus, hypothalamus and neocortex after aethimizol (1,5 mg/kg) and IEM-476 (3 mg/kg). Allylnorantifein and IEM-474 (both 3 mg/kg) shifted the amplitude and frequency of multiminute waves of infraslow activity in the reticular formation of the mesencephalon, in the medial group of thalamic nuclei, and the neocortex, i. e. the structures of the nonspecific ascending brain system, and failed to affect the brain temperature. The effects of IEM-476 and IEM-474 were shorter in duration, than those of aethimizol and allylnorantifein.
Authors Borodkin YuS, P D Shabanov, I A Lapina, I K Yaitchnikov
JournalActivitas nervosa superior (Act Nerv Super (Praha)) Vol. 26 Issue 2 Pg. 97-102 (Jun 1984) ISSN: 0001-7604 [Print] CZECHOSLOVAKIA
PMID6475479 (Publication Type: Journal Article)
Chemical References
  • Imidazoles
  • Antiphein
Topics
  • Animals
  • Avoidance Learning
  • Behavior, Animal (drug effects)
  • Body Temperature (drug effects)
  • Brain (drug effects, physiology)
  • Electrophysiology
  • Electroshock
  • Imidazoles (pharmacology)
  • Male
  • Memory (drug effects)
  • Rats
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: