[Circulating lipid-bound sialic acid levels in patients with malignant tumors].

Abstract

Lipid-bound sialic acids were estimated in blood serum of 118 patients with tumors, of 13 donors and of 38 patients with non-tumoral diseases. Content of the sialic acids in blood serum of the patients with growing tumors constituted 23.1 +/- 1.1 mg/100 ml, which was 2-2.5-fold higher as compared with healthy donors (10.5 +/- 0.4 mg/100 ml) or with the patients with non-tumoral diseases (13.8 +/- 0.5 mg/100 ml). In the oncologic patients during the remission period the content of lipid-bound sialic acids in blood serum approached the normal level - 12.1 +/- 0.5 mg/100 ml. The highest level of the sialic acids was found in patients with lymphogranulomatosis II-IV step, with melanoma during the period of growth, with kidney tumor and with liver tissue primary tumor. Estimation of circulating lipid-bound sialic acids in the oncologic patients may serve as a test for evaluation of the tumor growth as well as of therapeutic treatment efficiency.

• Authors: L S Bassalyk, A M Novikov, V D Sokolova, E N Sorokin
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1984 May-Jun Vol. 30 Issue 3 Pg. 124-7 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Urovni tsirkuliruiushchikh lipidno-sviazannykh sialovykh kislot u bol'nykh so zlokachestvennymi novoobrazovaniiami.
• PMID: 6474937 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Lipids
• Sialic Acids

Topics

• Female
• Humans
• Lipids (blood)
• Male
• Neoplasm Recurrence, Local (blood)
• Neoplasms (blood, therapy)
• Sialic Acids (blood)
• Spectrophotometry