Pulmonary vascular effects of furosemide on gas exchange in pulmonary edema.

Abstract

To test the hypothesis that pulmonary vasoactivity of furosemide redistributes blood away from edematous lung, thus improving gas exchange, we studied two groups of 10 dogs each with unilobar oleic acid edema, treating one group with 1 mg/kg furosemide 2 h after the oleic acid. Pulmonary perfusion distribution was determined with radio microspheres. Shunts of the injured lobe, measured from O2 contents of lower lobar pulmonary venous blood, increased significantly (P less than 0.05) at 2 h after injury in both groups. Within 0.5 h after furosemide the lobar shunt decreased in the treated animals from 40.1 +/- 20.6 to 28.6 +/- 20.1% and increased from 21.4 +/- 14.0 to 53.8 +/- 26.9% in the control group (P less than 0.05). Mean fractional lobar perfusion to the injured lobe increased from 18.2 +/- 4.8 to 21.6 +/- 6.4% (P less than 0.05) in the furosemide group but decreased from 20.1 +/- 3.5 to 16.1 +/- 4.4% (P less than 0.05) in the controls. Wet lung-to-body weight ratios of the edematous lobes did not differ between the two groups. Our data suggest the possibility that, before decreasing edema, furosemide improved shunt through pulmonary vascular effects by preferential perfusion of nonflooded alveolar units.

• Authors: J Ali, L D Wood
• Journal: Journal of applied physiology: respiratory, environmental and exercise physiology (J Appl Physiol Respir Environ Exerc Physiol) Vol. 57 Issue 1 Pg. 160-7 (Jul 1984) ISSN: 0161-7567 [Print] United States
• PMID: 6469777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oleic Acids
• Furosemide

Topics

• Animals
• Dogs
• Furosemide (pharmacology)
• Hemodynamics
• Oleic Acids (toxicity)
• Pulmonary Circulation (drug effects)
• Pulmonary Edema (chemically induced, physiopathology)
• Pulmonary Gas Exchange (drug effects)