[Therapy of gonarthrosis using chondroprotective substances. Prospective comparative study of glucosamine sulphate and glycosaminoglycan polysulphate].

Abstract

68 patients with mild or moderate gonarthritis were treated with intra-articular injections of glucosamine sulphate or glycosaminoglycan polysulphate over a period of six weeks. The therapy was successful in two thirds of these patients. "Loading" pain was eliminated or improved in about 80%, "getting-going" pain in about 64%, and signs of synovialitis in about 66%. Gait function and mobility were improved. Glucosamine had a superior effect, in particular in mild arthritis, achieving an improvement of pain in 90%, while glycosaminoglycan polysulphate was successful in advanced cases. The tolerance of the two substances was 94%. The results and the underlying modes of action of the substances are discussed.

• Authors: H J Hehne, K Bläsius, H U Ernst
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 102 Issue 24 Pg. 676-82 (Jun 28 1984) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Die Therapie der Gonarthrose mit chondroprotektiven Substanzen. Prospektive Vergleichsstudie zwischen Glukosaminsulfat und Glykosaminoglykanpolysulfat.
• PMID: 6469181 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Glycosaminoglycans
• Proteoglycans
• A73025

Topics

• Arthritis (drug therapy)
• Cartilage, Articular (drug effects, metabolism)
• Female
• Glycosaminoglycans (pharmacology, therapeutic use)
• Humans
• Knee Joint
• Male
• Middle Aged
• Prospective Studies
• Proteoglycans (biosynthesis)