[Comparative evaluation of mexiletine and propafenone by dynamic electrocardiography].

Abstract

We have compared the efficacy of Propafenon and Mexiletine in 12 subjects (7 males and 5 females, age range of 22-61 year) affected by chronic ventricular extrasystolic beats. Propafenon and Mexiletine were orally administered in doses of 900 mg/day and 600 mg/day respectively in a single blind, cross-over fashion. Our results show that: Propafenon is better tolerated; Propafenon has caused a statistically significant reduction of the total number of ventricular ectopic beats/24 hours; the efficacy of Propafenon has been greater than that of Mexiletine (66% and 25% respectively); with both drugs, in 2 cases, there was an increase of the total number of ventricular ectopic beats/24 hours; Propafenon has induced clear-cut electrocardiogram changes (statistically significant lengthening of P-Q and Q-T intervals).

• Authors: M Marzegalli, M Bernasconi, G Brambilla, T Micheletti, S Potenza, F Regalia, L Barbaresco, M Bossi
• Journal: Giornale italiano di cardiologia (G Ital Cardiol) Vol. 14 Issue 5 Pg. 352-6 (May 1984) ISSN: 0046-5968 [Print] Italy
• Vernacular Title: Valutazione comparativa tra mexiletina e propafenone mediante elettrocardiogramma dinamico.
• PMID: 6468816 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Propiophenones
• Propylamines
• Mexiletine
• Propafenone

Topics

• Adult
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (drug therapy)
• Drug Evaluation
• Electrocardiography (methods)
• Female
• Humans
• Male
• Mexiletine (therapeutic use)
• Middle Aged
• Propafenone
• Propiophenones (therapeutic use)
• Propylamines (therapeutic use)