Differential sensitivity of pinna reflex and esophageal temperature to clonidine in mice depleted of central noradrenaline by DSP-4.

Abstract

Mice injected with DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine], a selective noradrenergic neurotoxin, had marked depletions of central noradrenaline and an attenuated post-decapitation reflex. DSP-4-treated mice exhibited an increased sensitivity to the alpha 2-adrenoceptor agonist clonidine as measured by inhibition of the pinna reflex, but normal sensitivity as measured by hypothermia. This differential sensitivity may reflect the presence of supersensitive postsynaptic alpha 2-adrenoceptors in some, but not all, CNS regions after DSP-4 treatment.

• Authors: U Lerner, A Larsson
• Journal: Experientia (Experientia) Vol. 40 Issue 9 Pg. 963-5 (Sep 15 1984) ISSN: 0014-4754 [Print] Switzerland
• PMID: 6468623 (Publication Type: Journal Article)

Chemical References

• Amines
• Benzylamines
• Neurotoxins
• apraclonidine
• Clonidine
• DSP 4
• Norepinephrine

Topics

• Amines (pharmacology)
• Animals
• Benzylamines (pharmacology)
• Body Temperature (drug effects)
• Central Nervous System (metabolism)
• Clonidine (analogs & derivatives, pharmacology)
• Ear
• Male
• Mice
• Neurotoxins
• Norepinephrine (deficiency)
• Reflex (drug effects)