Medication of broilers with
arprinocid [9-(2-chloro-6-fluorophenylmethyl)-9H-
purine-6-
amine] gave protection against the effects of
coccidiosis in both battery and floor-pen trials. In battery trials, efficacy was tested on single-species inoculations of Eimeria acervulina, E. mivati, E. necatrix, E. maxima, E. Brunetti, and E. tenella. Two strains of each species recently recovered from the field, were tested separately. In floor-pen trials, all six species, both field and laboratory strains, were used as a
mixed infection. In batteries, 60 and 70 ppm essentially eliminated
coccidiosis-induced mortality and weight depression. Effects of 50 ppm on
weight gain were variable. The effectiveness of different medication levels varied between strains within a species. In floor-pen trials, 40, 60, or 80 ppm was effective in controlling mortality and weight depression, and increasing feel-conversion ratios. All levels were significantly as effective as
monensin in protecting against
coccidiosis. With severe exposure to coccidia, 60 and 80 ppm gave significantly lower lesion socres than did 40 ppm of
arprinocid or 120 ppm
monensin.