Abstract |
A comprehensive study of the scientific literature regarding tin content in normal and pathogenic human tissue has disclosed that various organotin materials retard both the onset and growth of cancer in laboratory animals, and decreased tissue tin in humans may be associated with tumour development. Initial studies by the authors have shown that the thymus gland of the mouse possesses a relatively high concentration of tin and is also the major site of accumulation for 14C-labelled tri-n-butyltin fluoride (TBTF). When mammary cancer-prone mice with transplanted tumours were orally dosed continuously with this agent in their drinking water, the tumour growth rate was significantly reduced. Both mouse mammary tumours and human lung tumours show low tin content compared to normal body tissue.
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Authors | N F Cardarelli, B M Quitter, A Allen, E Dobbins, E P Libby, P Hager, L R Sherman |
Journal | The Australian journal of experimental biology and medical science
(Aust J Exp Biol Med Sci)
Vol. 62 ( Pt 2)
Pg. 199-208
(Apr 1984)
ISSN: 0004-945X [Print] Australia |
PMID | 6466207
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Humans
- Lung Neoplasms
(analysis)
- Mice
- Neoplasm Transplantation
- Neoplasms
(analysis)
- Organotin Compounds
(analysis)
- Thymus Gland
(analysis)
- Tin
(physiology)
- Tissue Distribution
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