Abstract |
A patient initially diagnosed on surface marker status as having T cell chronic lymphatic leukaemia (T-CLL) was found to have arthropathy and recurrent pulmonary infarction associated with a high anti- DNA antibody titre. The T cell from this patient, on assessment in an in vitro pokeweed mitogen driven B cell system, demonstrated suppressor and helper characteristics but lacked antibody dependent cellular cytotoxicity (ADCC) activity and natural killer (NK) activity. Using peripheral blood mononuclear cells ( PBM) from patients with Hashimoto's thyroiditis and normals, it was shown that the patient's T cells suppressed both IgG and thyroid autoantibody production. Irradiation of the patient's PBM inhibited the suppressor effect and a residual helper effect remained. The patient was treated with systemic steroids for exacerbations of arthropathy which caused a fall in lymphocyte count. After 36 months the DNA binding activity spontaneously improved and the lymphocytosis disappeared. It is indicated that T-cell proliferations demonstrating functional activity must be assessed within the context of any underlying non-haematological clinical and laboratory findings.
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Authors | S J Proctor, A M McGregor, J Clark, S McLachlan, A Dickinson |
Journal | British journal of haematology
(Br J Haematol)
Vol. 50
Issue 2
Pg. 231-40
(Feb 1982)
ISSN: 0007-1048 [Print] England |
PMID | 6460523
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Immunoglobulin G
- DNA
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Topics |
- Adult
- Antibody-Dependent Cell Cytotoxicity
- Autoantibodies
(biosynthesis)
- Cell Division
- Cells, Cultured
- DNA
(immunology)
- Female
- Humans
- Immunoglobulin G
(biosynthesis)
- Lymphoproliferative Disorders
(immunology)
- T-Lymphocytes
(immunology)
- T-Lymphocytes, Regulatory
(immunology)
- Thyroiditis, Autoimmune
(immunology)
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