Abstract |
Thiamphenicol, an aminic derivative of hydrocarbilsulfonylpropandiol, was used for the treatment of acute, uncomplicated, gonococcal urethritis in 1,446 male patients. Each patient received one oral dose of 2.5 g of thiamphenicol, which was readministered after 48-72 hr if Neisseria gonorrhoeae continued to be present in urethral smears. Of the 1,446 patients treated, 1,230 patients underwent posttreatment evaluation at 48-72 hrs and at seven days. Twenty-eight patients (2.3%) did not respond to treatment; treatment was successful in 1,140 patients (92.7%) after only one dose, and in 62 (5.0%) after two doses. The overall rate of treatment success was 97.7%. Of 352 patients evaluated one month after treatment, serologic tests in 41 (12.6%) were positive for syphilis.
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Authors | W Belda, M F dos Santos Júnior, W Belda Jr |
Journal | Sexually transmitted diseases
(Sex Transm Dis)
1984 Oct-Dec
Vol. 11
Issue 4 Suppl
Pg. 418-9
ISSN: 0148-5717 [Print] United States |
PMID | 6441284
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Drug Evaluation
- Follow-Up Studies
- Gonorrhea
(drug therapy, microbiology)
- Humans
- Male
- Middle Aged
- Neisseria gonorrhoeae
(isolation & purification)
- Thiamphenicol
(therapeutic use)
- Urethra
(microbiology)
- Urethritis
(drug therapy, etiology)
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