[Experimental study on the significance of arachidonic acid metabolism in the pathogenesis of bronchial asthma with an in vivo model in the guinea pig].

Abstract

In anaesthetized artificially ventilated guinea-pigs from two breeds were produced histamine-induced bronchoconstrictions after pretreatment with acetylsalicylic acid (ASS) and/or para-amino-methylbenzoic acid (PAMBA). It was detected a distinct but adverse action of ASS on the intensity of bronchoconstriction in both animal groups. PAMBA was without any effect alone but mostly inhibited ASS-action. Since PAMBA inhibits phospholipase-A2 and ASS inhibits cyclooxygenase--both key-enzymes of arachidonic acid metabolism--the findings are estimated as a hint to the role of arachidonic acid metabolism in our animal model of asthma.

• Authors: G Becher, J Slapke, A Oddoy
• Journal: Zeitschrift fur Erkrankungen der Atmungsorgane (Z Erkr Atmungsorgane) Vol. 163 Issue 2 Pg. 166-74 ( 1984) ISSN: 0303-657X [Print] Germany
• Vernacular Title: Experimentelle Untersuchung zur Bedeutung des Arachidonsäurestoffwechsels in der Pathogenese des Asthma bronchiale mit einem In-vivo-Modell am Meerschweinchen.
• PMID: 6438929 (Publication Type: Journal Article)

Chemical References

• Arachidonic Acids
• Arachidonic Acid
• Lipoxygenase
• Prostaglandin-Endoperoxide Synthases
• Phospholipases A
• Phospholipases A2

Topics

• Airway Resistance
• Animals
• Arachidonic Acid
• Arachidonic Acids (metabolism)
• Asthma (enzymology)
• Guinea Pigs
• Lipoxygenase (metabolism)
• Lung Volume Measurements
• Male
• Phospholipases A (metabolism)
• Phospholipases A2
• Prostaglandin-Endoperoxide Synthases (metabolism)
• Respiratory Hypersensitivity (enzymology)