[Experimental study on the significance of arachidonic acid metabolism in the pathogenesis of bronchial asthma with an in vivo model in the guinea pig].

In anaesthetized artificially ventilated guinea-pigs from two breeds were produced histamine-induced bronchoconstrictions after pretreatment with acetylsalicylic acid (ASS) and/or para-amino-methylbenzoic acid (PAMBA). It was detected a distinct but adverse action of ASS on the intensity of bronchoconstriction in both animal groups. PAMBA was without any effect alone but mostly inhibited ASS-action. Since PAMBA inhibits phospholipase-A2 and ASS inhibits cyclooxygenase--both key-enzymes of arachidonic acid metabolism--the findings are estimated as a hint to the role of arachidonic acid metabolism in our animal model of asthma.
AuthorsG Becher, J Slapke, A Oddoy
JournalZeitschrift für Erkrankungen der Atmungsorgane (Z Erkr Atmungsorgane) Vol. 163 Issue 2 Pg. 166-74 ( 1984) ISSN: 0303-657X [Print] GERMANY, EAST
Vernacular TitleExperimentelle Untersuchung zur Bedeutung des Arachidonsäurestoffwechsels in der Pathogenese des Asthma bronchiale mit einem In-vivo-Modell am Meerschweinchen.
PMID6438929 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Arachidonic Acids
  • Arachidonic Acid
  • Lipoxygenase
  • Prostaglandin-Endoperoxide Synthases
  • Phospholipases A
  • Phospholipases A2
  • Airway Resistance
  • Animals
  • Arachidonic Acid
  • Arachidonic Acids (metabolism)
  • Asthma (enzymology)
  • Guinea Pigs
  • Lipoxygenase (metabolism)
  • Lung Volume Measurements
  • Male
  • Phospholipases A (metabolism)
  • Phospholipases A2
  • Prostaglandin-Endoperoxide Synthases (metabolism)
  • Respiratory Hypersensitivity (enzymology)

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